Decoding Complement Biology

to Redefine Disease Intervention

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Research Mission

Our research focuses on understanding how dysregulation of the complement system drives chronic inflammatory disease and on identifying precise intervention points to restore immune balance.

By combining deep complement biology expertise with translational science, we aim to identify precise intervention points where restoring immune balance may alter disease progression.


We concentrate on areas of high unmet medical need where complement overactivation is increasingly recognised as a central driver of pathology.

The Complement System

is a core component of innate immunity

Comprising more than 50 circulating and membrane-bound proteins, it functions as a rapid-response defence network, enhancing pathogen clearance, orchestrating inflammation, and supporting tissue surveillance.


Under normal physiological conditions, complement activation is tightly regulated. Precise control is essential to maintain tissue integrity while preserving immune protection.


Chronic complement overactivation is a central driver of inflammation and progressive retinal cell loss in Geographic Atrophy.

Complement Dysregulation in Geographic Atrophy

Geographic Atrophy (GA) is the advanced form of dry age-related macular degeneration and a leading cause of irreversible vision loss.


Growing scientific evidence demonstrates that chronic overactivation of the complement system contributes to sustained retinal inflammation, cellular stress, and progressive degeneration within the macula.


Imbalanced complement signalling and membrane attack complex formation accelerate photoreceptor and retinal pigment epithelium loss, establishing complement dysregulation as a central biological driver of GA progression.

Complement Dysregulation in Geographic Atrophy

Geographic Atrophy (GA) is the advanced form of dry age-related macular degeneration and a leading cause of irreversible vision loss.


Growing scientific evidence demonstrates that chronic overactivation of the complement system contributes to sustained retinal inflammation, cellular stress, and progressive degeneration within the macula.


Imbalanced complement signalling and membrane attack complex formation accelerate photoreceptor and retinal pigment epithelium loss, establishing complement dysregulation as a central biological driver of GA progression.

Scientific Publication

Complement Amplification in Age-Related Macular Degeneration

A peer-reviewed review published in Immunological Reviews (2022)

Harnessing the understanding of the science enables a new generation of complement-directed therapeutics